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KMID : 0861020020170020085
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Korea Journal of Herbology
2002 Volume.17 No. 2 p.85 ~ p.93
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Effect of Sasunchungryangeum on Acute Edematous Lung Injury Induced by Skin Burn
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Abstract
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Objectives : The present study was conducted to determine whether administration of heat extracts of Sasunchungtyangeum has an inhibitory effect of neutrophil-derived oxidative injury following dermal scald burn in rats.
Methods: Acute lung injury was induced by scald burn (15% of TBSA) in rats. To identify acute lung edematous lung injury, 5 hrs after skin burn, protein concentrations and numbers of polymorphonuclear leukocytes in bronchoalveolar lavage (BAL) were measured. In addition, levels of lung KC (neutrophil chemoattractant cytokine) and activities of lung myeloperoxidas (MPO) were measured, and morphological changes were observed.
Results : Lung weight and concentration of BAL protein, the index of lung injury were clearly increased at 5 hrs postburn compared to them of sham. Administration of heat extracts of Sasunchunryangeum after scald burn inhibited the production of KC in lung tissue and decreased the activity of lung MPO related to influx of neutrophils. In histological changes, edematous lung injury with infiltration of inflammatory cells induced by skin burn were decreased by administration of heat extracts of Sasunchunryangeum after scald burn.
Conclusions : These results suggest that Sasunchunryangeum may be a successful medical stuff in acute lung injury by skin burn.
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